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New Jersey Sports Medicine Regenerative Orthopedics |
Regenerative Medicine is the field of medicine dedicated to repairing or regrowing damaged tissue. Rejuvenation is the boosting of the body's natural ability to heal itself. Dr. Silberman trained under one of the pioneers in the field of regenerative medicine, Dr. Brian Shiple, while a fellow at the Crozer Chester Medical Center Sports Medicine Institute. The two most promising recent advances in sports medicine and the field of regenerative orthopedic medicine are platelet rich plasma (PRP) therapy and adult mesenchymal stem cell therapy, both performed by Dr. Silberman. Platelet Rich Plamsa (PRP) $600 for one joint Platelet rich plasma therapy or PRP is a treatment where your own blood (autologous blood therapy) in a concentrated form of platelets (rich in growth factors and cytokines) is injected into an injured muscle, tendon, ligament, or arthritic joint to treat pain, improve function, and stimulate your own body to heal damaged tissue. Over 300 molecules are released by platelets when injected into your body accelerating the natural healing process and promoting cartilage repair (Moussa et al in Experimental Cell Research, February 2017). Platelet Rich Plasma therapy (PRP) can be used for both acute and chronic injuries. PRP is beneficial for arthritis and cartilage injuries: A 2017 article demonstrates how Platelet Rich Plasma (PRP) protects against cartilage degradation in arthritis by 1. increasing the proliferation of chondrocytes, the only cells located in cartilage, whose job it is to produce and maintain your cartilage, 2. reversing senescence (deterioration with age) and increasing quiescent cells (non-aging cells that can withstand stress and preserve key functional features ), and by 3. significantly decreasing chondrocyte apoptosis (cell death). PRP is beneficial for tendon injuries: An injection of PRP in a torn achilles tendon stimulates early phase of tendon healing and ultimately resulted in a stronger tendon more resistant to rupture. PRP is beneficial for ligament injuries: PRP therapy was successful in returning high level baseball players with UCL (ulnar collateral ligament) partial thickness tears to competition much earlier than those treated conservatively. To read more on New Jersey Platelet Rich Plasma (PRP) Therapy click here. Stem Cell Therapy $2000 for one joint Adult bone marrow contains powerful multipotent progenitor cells called mesenchymal stem cells (MSCs). These stem cells have two important properties. They can differentiate into bone, cartilage, muscle, tendon, ligament, and other connective tissue and thus, have great potential for use in rebuilding damaged or diseased tissue. Second, they secrete a large array of bioactive molecules, similar to PRP, that provide a regenerative microenvironment to limit the area of damage in diseased tissue and to mount a self regulated regenerative response, referred to as trophic or nutritional activity (Arnold Caplan, Adult Mesenchymal Stell Cells for Tissue Engineering Versus Regenerative Medicine, Journal of Cellular Physiology, 2007). These bioactive factors inhibit scarring, inhibit cell death (aptosis), stimulate new blood vessel formation, and stimulates the mitosis of intrinsic tissue stem cells (where one cell divides to become two identical cells). Dr. Silberman obtains these stem cells from your bone marrow using a novel patent pending FDA approved bone marrow aspiration needle from Marrow Cellution, that requires only one puncture, 10cc of aspiration, and no manipulation or processing of the bone marrow. Some have even described the procedure as painless. It is a closed system, direct from your body back into your body, targeted under ultrasound guidance and delivered directly to your site of injury, disease, or damage. Bone marrow aspirate stem cell therapy has been used successfully in treatment of cancers, cardiomyopathy, chronic stroke, spinal cord injury, and myocardial infarction (heart attack). Be wary of testimonials though as these do not constitute science. In a 2015 randomized controlled study, bone marrow derived mesenchymal stem cells were found to provide pain relief in the treatment of osteoarthritis and improved cartilage appearance on MRI. A systemic review on bone marrow aspirate stem cell therapy in orthopedics has shown bone marrow aspirate concentrate has been used in bone, cartilage, and tendon injuries with encouraging results, with more research needed (Imam et al., Orthopedic Reviews 2016). A clear benefit in human and animal models has also been demonstrated in the treatment of cartilage injuries for which microfracture has been less than successful in clinical experience (Holton et al. Orthop Rev 2016). Is bone marrow aspirate or adipose tissue stem cell injection for everyone? No. I have seen many athletes and patients come from other locations treated with stem cell therapy, prolotherapy, ozone, prolozone, and/or PRP when they should not have been treated with these often over priced out of pocket treatments at regenerative institutes. Dr. Silberman has treated failures from the "Kobe" Clinic in Germany where stem cells are cultured outside of the body, patients operated on at the Hospital for Special Surgery (HSS), and patients referred from the Cleveland Clinic. Nobody is bigger than medicine, so don't be fooled by snake oil salesmen at regenerative institutes and stem cell centers. Be wary of testimonials, as they do not constitute science. To read more on New Jersey Stem Cell Therapy click here. |
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